You and Me, alternatively stylized as You & Me, may refer to:
- Music
- "You & Me", first English special single by Jennie
- You & Me, second mini album by KARD
- "You and Me", first digital single by Kim Ho Joong
- "You and Me", debut digital single by Lee Chan Sol
- "You&Me", ninth Japanese digital single by SUPER JUNIOR-D&E
- You&Me, second mini album by SUPER JUNIOR-D&E