On May 11, 2018, she was revealed as a contestant on Produce 48, where she would be representing Yue Hua Entertainment. She ranked 4th overall, thus becoming a member of IZ*ONE. The group officially debuted on October 29 with their first mini album Color*IZ.
Her Produce 48 motto was "Yena; now born as a person of many talents", while her catchphrase was "I shall become a person like you've never seen before."
Ye Na is a cancer survivor. She had childhood lymphoma. Her illness was so severe that doctors told her parents to give up. Due to her family's financial situation and medical costs, her parents never got the chance to have a honeymoon and went out every morning to sell gimbap. Due to this, she has an old tracheal tube scar visible on the lower front of her neck.